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Journal Article 6

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pharmacological mechanism 2

Coptis chinensis 1

adjuvant-induced arthritis 1

adverse effect 1

anesthetic pharmacological study 1

berberine 1

clinical applications 1

community 1

control of blood pressure 1

emulsified isoflurane (EI) 1

general anesthesia 1

hypertension 1

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pKa calculation 1

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A novel intravenous general anesthetic--- emulsified isoflurane: from bench to bedside

Cheng Zhou, Jin Liu

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 381-387 doi: 10.1007/s11684-012-0229-z

Abstract: There are obvious advantages of volatile anesthetics such as strong anesthetic potency, rapid onset andEmulsified isoflurane, the emulsion of isoflurane, is a novel intravenous general anesthetic.intravenous general anesthesia to various fields including regional anesthesia, organ protection, as well as anestheticpharmacological study.

Keywords： emulsified isoflurane (EI)     general anesthesia     regional anesthesia     organ protection     anesthetic pharmacological    

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Deciphering the pharmacological mechanism of Guan-Jie-Kang in treating rat adjuvant-induced arthritis

Hudan Pan, Yanfang Zheng, Zhongqiu Liu, Zhongwen Yuan, Rutong Ren, Hua Zhou, Ying Xie, Liang Liu

Frontiers of Medicine 2019, Volume 13, Issue 5,   Pages 564-574 doi: 10.1007/s11684-018-0676-2

Abstract: Traditional Chinese medicine (TCM) formulas have attracted increasing attention worldwide in the past few years for treating complex disease including rheumatoid arthritis. However, their mechanisms are complex and remain unclear. Guan-Jie-Kang (GJK), a prescription modified from “Wu Tou Decoction,” was found to significantly relieve arthritis symptoms in rats with adjuvant-induced arthritis after 30-day treatment, especially in the 24 g/kg/day group. By analyzing 1749 targets related to 358 compounds in the five herbs of GJK, we identified the possible anti-arthritis pathways of GJK, including the calcium signaling and metabolic pathways. Bone damage levels were assessed by micro-computed tomography, and greater bone protective effect was observed with GJK treatment than with methotrexate. Receptor activator of nuclear factor κB ligand (RANKL)–RANK signaling, which is related to calcium signaling, was significantly regulated by GJK. Moreover, a target metabolomics assay of serum was conducted; 17 metabolic biomarkers showed significant correlations with treatment. An integrated pathway analysis revealed that pyruvate metabolism, purine metabolism, and glycolysis metabolism were significantly associated with the effects of GJK in arthritis treatment. Thus, this study establishes a new omics analytical method integrated with bioinformatics analysis for elucidating the multi-pathway mechanisms of TCM.

Keywords： rheumatoid arthritis     traditional Chinese medicine     pharmacological mechanism     metabolism     adjuvant-induced    

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Biological properties and clinical applications of berberine

Danyang Song, Jianyu Hao, Daiming Fan

Frontiers of Medicine 2020, Volume 14, Issue 5,   Pages 564-582 doi: 10.1007/s11684-019-0724-6

Abstract: , an isoquinoline alkaloid isolated from the Chinese herb and other plants, has a wide range of pharmacologicalThis article summarizes the main pharmacological actions of berberine and its mechanisms in cancer and

Keywords： berberine     Coptis chinensis     pharmacological properties     mechanism     clinical applications    

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Cell Therapy: Pharmacological Intervention Enters a Third Era

Wei He

Engineering 2019, Volume 5, Issue 1,   Pages 5-9 doi: 10.1016/j.eng.2018.11.017

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design of novel proton-pump inhibitors with reduced adverse effects

Xiaoyi Li, Hong Kang, Wensheng Liu, Sarita Singhal, Na Jiao, Yong Wang, Lixin Zhu, Ruixin Zhu

Frontiers of Medicine 2019, Volume 13, Issue 2,   Pages 277-284 doi: 10.1007/s11684-018-0630-3

Abstract: The development of new proton-pump inhibitors (PPIs) with less adverse effects by lowering the pKa values of nitrogen atoms in pyrimidine rings has been previously suggested by our group. In this work, we proposed that new PPIs should have the following features: (1) number of ring II= number of ring I+ 1; (2) preferably five, six, or seven-membered heteroatomic ring for stability; and (3) 1

Keywords： proton-pump inhibitor     adverse effect     pharmacological mechanism     toxicological mechanism     pKa calculation    

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Effectiveness of lifestyle intervention for hypertension in Shanghai communities: Results from the Shanghai Hypertension Detail Management Program

Xin-Jian LI MD, Min-Na CHENG MPH, Yu-Heng WANG MD, Sun MIAO MPH, Zong-Qi ZHANG PhD, Yi-Sheng CHEN MD, Wei LU PhD,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 67-70 doi: 10.1007/s11684-010-0023-8

Abstract: The net change extent was larger in patients with regular pharmacological treatment than in those withirregular pharmacological treatment or non-pharmacological treatment.

Keywords： hypertension     community     pharmacological adherence     control of blood pressure    

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Title Author Date Type Operation

A novel intravenous general anesthetic--- emulsified isoflurane: from bench to bedside

Cheng Zhou, Jin Liu

Journal Article

Deciphering the pharmacological mechanism of Guan-Jie-Kang in treating rat adjuvant-induced arthritis

Hudan Pan, Yanfang Zheng, Zhongqiu Liu, Zhongwen Yuan, Rutong Ren, Hua Zhou, Ying Xie, Liang Liu

Journal Article

Biological properties and clinical applications of berberine

Danyang Song, Jianyu Hao, Daiming Fan

Journal Article

Cell Therapy: Pharmacological Intervention Enters a Third Era

Wei He

Journal Article

design of novel proton-pump inhibitors with reduced adverse effects

Xiaoyi Li, Hong Kang, Wensheng Liu, Sarita Singhal, Na Jiao, Yong Wang, Lixin Zhu, Ruixin Zhu

Journal Article

Effectiveness of lifestyle intervention for hypertension in Shanghai communities: Results from the Shanghai Hypertension Detail Management Program

Xin-Jian LI MD, Min-Na CHENG MPH, Yu-Heng WANG MD, Sun MIAO MPH, Zong-Qi ZHANG PhD, Yi-Sheng CHEN MD, Wei LU PhD,

Journal Article